Limited progression of subclinical Dupuytren’s disease

Aims With novel promising therapies potentially limiting progression of Dupuytren’s disease (DD), better patient stratification is needed. We aimed to quantify DD development and after seven years in a population-based cohort, identify factors predictive or progression. Methods All surviving participants from our previous prevalence study were invited participate the current prospective cohort study. Participants examined for presence Iselin’s classification was applied. They asked complete comprehensive questionnaires. Disease defined as advancement further Iselin stage surgery. Potential assessed using multivariable regression analyses. Of 763 original study, 398 available investigation later. Results identified 143/398 (35.9%) with DD, whom 56 (39.2%) newly diagnosed. Overall, 20/93 (21.5%) previously affected had progression, while 6/93 (6.5%) patients showed regression. occurred more often who initially advanced disease. Multivariable analyses revealed that both ectopic lesions positive family history are independent predictors Previous hand injury predicts DD. Conclusion 21.5% The higher initial stage, greater proportion at follow-up. Both predict These patient-specific may be used might benefit treatment prevents Cite this article: Bone Joint J 2021;103-B(4):704–710.